Sodium Carbonate → HCID 68104456, compound

Participants

Reaction Conditions

Reaction Steps

The reaction mixture from Method F Step 1 was diluted with DMF (2 mL) an 2-bromo-5-isopropylsulfonyl-pyridine [Compound I-7a; prepared according to Method F-1] (48 mg, 0.1817 mmol), Pd(PPh3)2Cl2 (6.263 mg, 0.01514 mmol) and 2M aqueous Na2CO3 (227.1 μL, 0.4542 mmol) were added. The reaction was degassed with nitrogen and stirred at 95° C. for 2 hours in a sealed tube. The reaction mixture was partitioned between EtOAc and brine and the aqueous layer extracted with EtOAc (×2). The combined organic extracts were washed with brine (×3), dried (MgSO4), filtered and concentrated in vacuo. The crude residue was used in the deprotection step without further purification.

Provenance & Evidence