Azobisisobutyronitrile → HCID 68104457, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate (245 mg, 0.3860 mmol) was suspended in EtOAc (2.5 mL) followed by the addition of NBS (89.31 mg, 0.5018 mmol) and AIBN (6.338 mg, 0.03860 mmol). The mixture was heated to 85° C. and placed under a bright lamp for 2 hours. The reaction mixture was cooled to ambient temperature and washed with saturated aqueous NaHCO3/brine (1:1, ×2), dried (MgSO4), filtered and concentrated in vacuo to give the impure sub-title compound as a pale brown foam. This was used in the next step without any further purification.

Provenance & Evidence