Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 7-chloro-5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | (2-Bromoethyl)cyclohexane | HCID 15440 | — |
| 반응물 | m-Chlorophenylhydrazine hydrochloride | HCID 75331 | — |
| 반응물 | 1-Methylpiperidin-4-one hydrochloride | HCID 12210057 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 7-chloro-5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole | HCID 57876276 | — |
| 생성물 | HCID 57876332 | HCID 57876332 | — |
반응 단계
Preparation of the title compounds was carried out according to General Method 8. 3-Chlorophenylhydrazine hydrochloride (5 g, 27.9 mmol), 1-bromo-2-cyclohexylethane (4.37 ml, 27.9 mmol), triethyl amine (11.66 ml, 83.7 mmol) and N-methyl-4-piperidone hydrochloride (4 g, 27.9 mmol) were combined in ethanol (30 ml) to obtain 9-chloro-5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole and 7-chloro-5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole after on purification on silica gel (230-400 mesh) chromatography eluting with acetone-hexane gradient. The free base was converted into its oxalate salt by treatment of oxalic acid (1 equiv.) in anhydrous THF.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09096591B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-1564acdc7f36434fab43113793b63974 |
| 출처 메모 | uspto-grants-2015_08 |