Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 5-(2-fluorophenethyl)-2,3,4,5-tetrahydro-8-iodo-2-methyl-1H-pyrido[4,3-b]indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Trifluoroacetate | HCID 84468 | — |
| 반응물 | 2-Fluorophenethyl bromide | HCID 2756964 | — |
| 반응물 | 4-Iodophenylhydrazine hydrochloride | HCID 12208795 | — |
| 반응물 | 1-Methylpiperidin-4-one hydrochloride | HCID 12210057 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-(2-fluorophenethyl)-2,3,4,5-tetrahydro-8-iodo-2-methyl-1H-pyrido[4,3-b]indole | HCID 57876246 | 0.5% |
반응 단계
Preparation of the title compound was carried out according to General Method 8. 4-Iodophenylhydrazine hydrochloride (500 mg, 2.1 mmol), 2-fluorophenethylbromide (0.3 ml, 2.1 mmol), triethyl amine (0.8 ml, 6.3 mmol) and N-methyl-4-piperidone hydrochloride (312 mg, 2.1 mmol) were taken in ethanol (10 ml) to obtain 5 mg of 5-(2-fluorophenethyl)-2,3,4,5-tetrahydro-8-iodo-2-methyl-1H-pyrido[4,3-b]indole as a trifluoroacetate salt after purification by reverse-phase chromatography (C-18, 500 mm×50 mm, Mobile Phase A=0.05% TFA in water, B=0.05% TFA in acetonitrile, Gradient: 10% B to 80% B in 30 min, injection vol. 5 mL).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09096591B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-521570ed17164ebaa0afba6f902f1fbf |
| 출처 메모 | uspto-grants-2015_08 |