HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-5-vinylpyridine → 2,3,4,5-tetrahydro-8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2-(4-nitrophenyl)-1H-pyrido[4,3-b]indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-5-vinylpyridine | HCID 8817 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2,3,4,5-tetrahydro-8-methyl-2-(4-nitrophenyl)-1H-pyrido[4,3-b]indole | HCID 68757485 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2,3,4,5-tetrahydro-8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2-(4-nitrophenyl)-1H-pyrido[4,3-b]indole | HCID 57876040 | — |
Reaction Steps
The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-8-methyl-2-(4-nitrophenyl)-1H-pyrido[4,3-b]indole, 2-methyl-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096591B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-7df5c2b1939c41fea66686c49ab84de0 |
| Source note | uspto-grants-2015_08 |