HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → HCID 57876328, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-Ethenyl-2-(trifluoromethyl)pyridine | HCID 57416848 | — |
| Reactant | HCID 59455009 | HCID 59455009 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 57876328 | HCID 57876328 | — |
Reaction Steps
The title compound is prepared from a mixture of 8-chloro-9-fluoro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole, 2-(trifluoromethyl)-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096591B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-6ab9ef530cbf48b2834f7fe74bb86d9d |
| Source note | uspto-grants-2015_08 |