Potassium Hydroxide → 8-chloro-5-(2-(4-(trifluoromethyl)-6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole

Participants

Role	Name	HCID	Charge
Reactant	Potassium Hydroxide	HCID 14797	—
Reactant	8-chloro-2-methyl-1H,2H,3H,4H,5H-pyrido(4,3-b)indole	HCID 19615	—
Reactant	Pyridine, 5-ethenyl-2-methyl-4-(trifluoromethyl)-	HCID 68734541	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	8-chloro-5-(2-(4-(trifluoromethyl)-6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole	HCID 57876389	—

Reaction Steps

The title compound is prepared from a mixture of 8-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole, 4-(trifluoromethyl)-2-methyl-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09096591B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-89e279d6bdd84520a262bc0953d0dfd4
Source note	uspto-grants-2015_08