Potassium Hydroxide → Ethyl 3-(6-(trifluoromethyl)pyridin-3-yl)-2-(1,2,3,4-tetrahydro-2,8-dimethylpyrido[4,3-b]indol-5-yl)propanoate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Potassium Hydroxide	HCID 14797	—
Edukt	1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2,8-dimethyl-	HCID 209291	—
Edukt	(Z)-ethyl 3-(6-(trifluoromethyl)pyridin-3-yl)acrylate	HCID 86634536	—
Lösungsmittel	N-methyl-2-pyrrolidone	HCID 13387	—
Produkt	Ethyl 3-(6-(trifluoromethyl)pyridin-3-yl)-2-(1,2,3,4-tetrahydro-2,8-dimethylpyrido[4,3-b]indol-5-yl)propanoate	HCID 57876010	—

Reaktionsschritte

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole, (Z)-ethyl 3-(6-(trifluoromethyl)pyridin-3-yl)acrylate and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09096591B2
Quelldatensatz	uspto-grants-2015_08
ORD ID	ord-97d0ed82e1d14c2c98afde650c3a2f3f
Quellennotiz	uspto-grants-2015_08