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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 509817Generated: November 4, 2026

Potassium Hydroxide → HCID 57876212, compound

https://huagongshe.com/reaction/509817

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2,8-dimethyl-HCID 209291—
ReactantHCID 68735010HCID 68735010—
SolventN-methyl-2-pyrrolidoneHCID 13387—
ProductHCID 57876212HCID 57876212—

Reaction Steps

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole, methyl 2-(6-(trifluoromethyl)pyridin-3-yl)acrylate and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09096591B2
Source datasetuspto-grants-2015_08
ORD IDord-4b500d6181a042c2822cd9ed134defe9
Source noteuspto-grants-2015_08