Potassium Hydroxide → 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)ethyl)-1H-pyrido[4,3-b]indole

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Potassium Hydroxide	HCID 14797	—
Edukt	1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2,8-dimethyl-	HCID 209291	—
Edukt	1-methyl-5-vinyl-1H-pyrrolo[2,3-b]pyridine	HCID 68757659	—
Lösungsmittel	N-methyl-2-pyrrolidone	HCID 13387	—
Produkt	2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)ethyl)-1H-pyrido[4,3-b]indole	HCID 57876090	—

Reaktionsschritte

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole, 1-methyl-5-vinyl-1H-pyrrolo[2,3-b]pyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09096591B2
Quelldatensatz	uspto-grants-2015_08
ORD ID	ord-35d4505dc5884fa09102b8b065a6bc4d
Quellennotiz	uspto-grants-2015_08