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Potassium Hydroxide → 5-(2-(8-chloro-1,2,3,4-tetrahydro-2-methylpyrido[4,3-b]indol-5-yl)ethyl)-N-methylpyridin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 8-chloro-2-methyl-1H,2H,3H,4H,5H-pyrido(4,3-b)indole | HCID 19615 | — |
| 反応物 | N-methyl-5-vinylpyridin-2-amine | HCID 68735488 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 5-(2-(8-chloro-1,2,3,4-tetrahydro-2-methylpyrido[4,3-b]indol-5-yl)ethyl)-N-methylpyridin-2-amine | HCID 57875965 | — |
反応手順
The title compound is prepared from a mixture of 8-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole, N-methyl-5-vinylpyridin-2-amine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09096591B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-c9e7d2c38b98427eaa12c5df898e2ff8 |
| 出典メモ | uspto-grants-2015_08 |