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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 509882Generated: October 25, 2026

Potassium Hydroxide → 5-(2-(4-(trifluoromethyl)pyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-8-isopropyl-2-methyl-1H-pyrido[4,3-b]indole

https://huagongshe.com/reaction/509882

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant2,3,4,5-tetrahydro-8-isopropyl-2-methyl-1H-pyrido[4,3-b]indoleHCID 59455219—
ReactantPyridine, 3-ethenyl-4-(trifluoromethyl)-HCID 68735093—
SolventN-methyl-2-pyrrolidoneHCID 13387—
Product5-(2-(4-(trifluoromethyl)pyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-8-isopropyl-2-methyl-1H-pyrido[4,3-b]indoleHCID 57875870—

Reaction Steps

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-8-isopropyl-2-methyl-1H-pyrido[4,3-b]indole, 4-(trifluoromethyl)-3-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09096591B2
Source datasetuspto-grants-2015_08
ORD IDord-f79bd32675c64d1d97c046d091e61d7f
Source noteuspto-grants-2015_08