Hydrochloric Acid → HCID 131733251, compound

Participants

Reaction Steps

(S)-3-tert-butoxycarbonylamino-1,1-bis-[3-(4-dimethylcarbamoylmethoxy-phenyl)-propyl]-piperidinium trifluoroacetate (150 mg, 0.2 mmol) is dissolved in tetrahydrofurane (2 ml) and 4 M HCl (2 ml), stirred at 50° C. for 30 minutes and concentrated in vacuo. The residue is dissolved in dioxane (10 ml), a solution of lithiumaluminumhydydride (200 μl, 0.2 mmol) is added and stirred at room temperature for 2 h. 1 M HCl (1 ml) is added to the reaction mixture and concentrated in vacuo. LC (method L): tR=0.63 min; Mass spectrum (ESI+): m/z=511 [M]+.

Provenance & Evidence