HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromide ion → HCID 117856852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromide ion | HCID 259 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| Reactant | 6-Methoxypyridine-3-carbaldehyde | HCID 3364576 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Product | HCID 117856852 | HCID 117856852 | — |
Reaction Steps
The title compound is prepared from 6-methoxy-3-pyridinecarboxaldehyde (0.5 g, Aldrich) by a sequence of standard transformations consisting of Wittig reaction with (carbethoxymethylene)triphenylphosphorane and NaOH, catalytic hydrogenation of the exocyclic C—C double bond, reduction to the corresponding alcohol with LiAlH4, and conversion to the bromide using N-bromosuccinimide and PPh3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096548B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-0cc5c2990a0f4943bf1e3d61d58e5a19 |
| Source note | uspto-grants-2015_08 |