反应详情

To [5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chloro-thiazol-2-yl]-carbamic acid tert-butyl ester (28, 4.30 g, 7.97 mmol) in 70.0 mL of dichloromethane, a solution of hydrogen chloride (42.0 mL, 4.00 M in 1,4-dioxane) was added. The reaction was stirred at room temperature for 2 days, then concentrated, and triturated with ethyl ether and ethyl acetate to provide the desired compound (29, 2.60 g, 74.2%). MS (ESI) [M+H+]+=439.0.

1. concentrationconcentrated
2. customtriturated with ethyl ether and ethyl acetate