HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-3-iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine → (3-Chloro-benzyl)-[5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-1-methyl-1H-pyrazol-3-yl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-3-iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine | HCID 24229230 | — |
| Reactant | 5-(3-chloro-benzylamino)-2-methyl-2H-pyrazole-3-carbaldehyde | HCID 57619172 | — |
| Product | (3-Chloro-benzyl)-[5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-1-methyl-1H-pyrazol-3-yl]-amine | HCID 58259317 | — |
Reaction Steps
(3-Chloro-benzyl)-[5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-1-methyl-1H-pyrazol-3-yl]-amine P-2006 was prepared in two steps from 5-(3-chloro-benzylamino)-2-methyl-2H-pyrazole-3-carbaldehyde 145 and 5-fluoro-3-iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine 146 as shown in Scheme 18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096593B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-6ec406bc3a5d4003a74a419190ff70e3 |
| Source note | uspto-grants-2015_08 |