HCID 57963111, compound → HCID 52933299, compound

HRID 510014Notes

Reaction equation

HRID 510014 reaction equation
C(OC(=O)[N:7]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[Cl:24])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]=O)=[C:10]([F:16])[N:9]=1)(C)(C)C.I[C:27]1[C:35]2[C:30](=[N:31][CH:32]=[C:33]([O:36][CH3:37])[CH:34]=2)[N:29]([Si](C(C)C)(C(C)C)C(C)C)[CH:28]=1>>[Cl:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:17][NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:27]2[C:35]3[C:30](=[N:31][CH:32]=[C:33]([O:36][CH3:37])[CH:34]=3)[NH:29][CH:28]=2)=[C:10]([F:16])[N:9]=1

Participants

3

Reactant 2

HCID 57963111HCID 57963111, compoundHCID 58259088HCID 58259088, compound

Product 1

HCID 52933299HCID 52933299, compound

Procedure

(2-Chloro-benzyl)-[6-fluoro-5-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-amine P-2034 was prepared in two steps from (2-chloro-benzyl)-(6-fluoro-5-formyl-pyridin-2-yl)-carbamic acid tert-butyl ester 48 and 3-iodo-5-methoxy-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine 5 as shown in Scheme 25.

Sources & evidence

ORD record
ord-df78f7dd31424a1d84115230fdfe3769
Source dataset
uspto-grants-2015_08
Patent number
US09096593B2

Reaction notes

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