HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-Bromo-o-fluorotoluene → 1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo(3,4-b)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-Bromo-o-fluorotoluene | HCID 67968 | — |
| Reactant | HCID 178506575 | HCID 178506575 | — |
| Product | 1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo(3,4-b)pyridine | HCID 57415891 | 95.7% |
Reaction Steps
In analogy to example 24A, 25.00 g (102.031 mmol) of 3-iodo-1H-pyrazolo[3,4-b]pyridine (synthesis described in WO 2006/130673, scheme D) were reacted with 21.21 g (112.234 mmol) of 2-fluorobenzyl bromide. 34.49 g of the title compound were obtained (95% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096592B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-3d737e3861c64c7d954f20937275303d |
| Source note | uspto-grants-2015_08 |