Lithium Hydroxide → HCID 66613960, compound

Participants

Reaction Steps

830 mg (2.20 mmol) of the compound from example 44A were initially charged in tetrahydrofuran (10 ml), 4.40 ml (4.40 mmol) of aqueous lithium hydroxide solution (1.0 M) were added and the suspension was stirred at RT for 90 min Subsequently, the now clear solution was concentrated and the residue was partitioned between ethyl acetate and water. The aqueous phase was adjusted to pH<7 with 1M hydrochloric acid, and a solid precipitated out. This was filtered off, washed with water and tert-butyl methyl ether, and dried under high vacuum. This gave 710 mg (89% of theory) of the title compound in solid form.

Provenance & Evidence