反应详情

592 mg (1.56 mmol) of the compound from example 53A were initially charged in pyridine (25 ml) and then 133 mg (0.125 mmol) of palladium (10% on charcoal) were added. The mixture was stirred at standard hydrogen pressure overnight. The suspension was then filtered through Celite and the filtercake was washed with methanol. The filtrate was concentrated, methanol was added and the mixture was filtered and concentrated again. The residue was dried under high vacuum. This gave 396 mg of the title compound (80% purity, 45% of theory), which were converted without further purification.

1. filtrationThe suspension was then filtered through Celite
2. washthe filtercake was washed with methanol
3. concentrationThe filtrate was concentrated
4. additionmethanol was added
5. filtrationthe mixture was filtered
6. concentrationconcentrated again
7. customThe residue was dried under high vacuum
8. customThis gave 396 mg of the title compound (80% purity, 45% of theory), which were converted without further purification