反应详情

400 mg (1.193 mmol) of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine (synthesis described in US2004/67937; Example V) were reacted in analogy to the method in example 88A with 1-(2,2,2-trifluoroethyl)pyrrolidinone. After purification by means of preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient), this gave 482 mg of the title compound (83% of theory).

1. customAfter purification by means of preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient)