Hydrochloric Acid → HCID 66614346, compound

Participants

Reaction Conditions

Reaction Steps

1000 mg (2.55 mmol) of ethyl 4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-5-carboxylate (example 101A) were suspended in 80 ml of dioxane and admixed cautiously with 50.1 ml (948 mmol) of aqueous sodium hydroxide solution (50% by weight). The mixture was then stirred at 60° C. for 4 h and then poured onto 200 ml of ice-water. Concentrated hydrochloric acid was used to cautiously adjust the mixture to pH 2, and the precipitate observed was removed by means of filtration. The precipitate was washed with a little water and finally dried under high vacuum. Thus, 993 mg (approx. 105% of theory, the batch probably still contained small amounts of inorganic salts) of the target compound were obtained.

Provenance & Evidence