反应详情

10.0 g (32.7 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride (example 5A) and 8.54 g (49.1 mmol) of dimethyl (methoxymethylene)malonate were initially charged in 400 ml of methanol, and 1.77 g (32.7 mmol) of sodium methoxide were added cautiously. The mixture was reacted at 50° C. overnight. The precipitate formed was filtered off, washed with a little methanol and dried under high vacuum. Thus, 6.54 g (52% of theory) of the target compound were obtained.

1. customThe mixture was reacted at 50° C. overnight
2. customThe precipitate formed
3. filtrationwas filtered off
4. washwashed with a little methanol
5. customdried under high vacuum
6. customThus, 6.54 g (52% of theory) of the target compound were obtained