Water → HCID 56928637, compound

Participants

Reaction Conditions

Reaction Steps

350 mg (0.833 mmol) of the compound obtained in example 6A were initially charged in 12 ml of tetrahydrofuran at 0° C. Then 1.665 ml of a 1M solution of bis(trimethylsilyl)sodium amide in tetrahydrofuran were added dropwise and the mixture was stirred at 0° C. for a further 10 min. The mixture was then stirred at RT overnight. Subsequently, 2 ml of water were added to the mixture, which was concentrated to dryness. The residue was purified by means of preparative HPLC (acetonitrile/water (+0.05% formic acid) gradient). 188 mg of the title compound were obtained (53% of theory).

Provenance & Evidence