HCID 56646457, compound → HCID 56928736, compound

Participants

Reaction Steps

132 mg (0.279 mmol) of the compound prepared in example 12A were dissolved in tetrahydrofuran (8 ml), and 0.307 ml of a 1M solution of bis(trimethylsilyl)sodium amide in tetrahydrofuran were added at 0° C. Stirring of the mixture at RT was continued overnight. This was followed by concentration and purification of the residue by means of preparative HPLC (eluent: acetonitrile/water with 0.05% formic acid, gradient). 81 mg of the title compound were obtained (62% of theory).

Provenance & Evidence