Potassium Carbonate → HCID 66613353, compound

Participants

Reaction Conditions

Reaction Steps

150 mg (0.382 mmol) of the compound from example 28 were dissolved in 2 ml of dimethylformamide, and 58 mg (0.420 mmol) of potassium carbonate were added. The mixture was heated to 70° C. for 10 min and, after cooling, 38 μl (0.382 mmol) of trifluoroethyl iodide were added and the mixture was stirred at RT for 16 h. The mixture was concentrated, and the residue was adsorbed on silica gel and purified by means of chromatography on silica gel (eluent: dichloromethane/methanol=20:1). 49 mg of the title compound were obtained (25% of theory).

Provenance & Evidence