Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | 2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amine | HCID 3513851 | — |
| Reactant | 6-Amino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one | HCID 66613627 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66614391 | HCID 66614391 | 31.2% |
Reaction Steps
200 mg (0.531 mmol) of the compound from example 33 and 146 mg (0.531 mmol) of BEMP were initially charged in 10 ml of dimethylformamide, and a solution of 82 mg (0.531 mmol) of ethyl iodide in 2 ml of dimethylformamide was added dropwise at 0° C. within 10 min The mixture was stirred at 0° C. for 20 min. Subsequently, the reaction solution was concentrated under reduced pressure and the residue was purified by means of preparative HPLC (eluent: acetonitrile/water, gradient 10:90→90:10). 67 mg of the title compound were obtained (31% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09096592B2 |
|---|
| Source dataset | uspto-grants-2015_08 |
|---|
| ORD ID | ord-964b39ea5b764909960bf1aaa8202348 |
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| Source note | uspto-grants-2015_08 |
|---|
