Trifluoroacetic acid → HCID 56928842, compound

Participants

Reaction Steps

96 mg (0.17 mmol) of the compound from example 41A were initially charged in dichloromethane (5 ml), then 0.13 ml (1.73 mmol) of trifluoroacetic acid were added and the reaction mixture was stirred at RT overnight. The mixture was concentrated, the residue was separated by means of preparative HPLC (eluent: acetonitrile-water with 0.1% formic acid gradient) and the product fractions were concentrated. This gave 52 mg (66% of theory) of the title compound in solid form.

Provenance & Evidence