Ethanolamine → 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-[(2-hydroxyethyl)amino]-7-methyl-7,9-dihydro-8H-purin-8-one

참여 물질

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반응 단계

200 mg (0.399 mmol) of the compound obtained in example 107 were dissolved in N-methylpyrrolidone (4 ml) and admixed with 2-aminoethanol (1.5 ml), and then heated in a microwavable flask with septum in a microwave at 150° C. for 5 h. The reaction mixture was purified by means of preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient). 31 mg of the title compound were obtained (18% of theory).

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