反应详情

200 mg (0.399 mmol) of the compound obtained in example 107 in pyridine (3 ml) were admixed with 37 mg (0.419 mmol) of copper(I) cyanide and heated to reflux overnight. After cooling, the reaction mixture was filtered and concentrated, and the residue was purified by means of preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient). 31 mg of the title compound were obtained (18% of theory).

1. temperatureheated
2. temperatureto reflux overnight
3. temperatureAfter cooling
4. filtrationthe reaction mixture was filtered
5. concentrationconcentrated
6. customthe residue was purified by means of preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient)