Triethylamine → HCID 66614271, compound

Participants

Reaction Conditions

Reaction Steps

520 mg (1.33 mmol) of the compound from example 61A were initially charged in dimethylformamide (5 ml), then 1.07 g (6.63 mmol) of N,N-carbonyldiimidazole and 2.31 ml (1.68 mmol) of triethylamine were added and the mixture was stirred at 100° C. overnight. The reaction mixture was then diluted with water and ethyl acetate, the phases were separated and the aqueous phase was extracted with ethyl acetate. The collected organic phases were dried over sodium sulfate, filtered and concentrated. The crude product (540 mg, 84% purity) was not purified any further.

Provenance & Evidence