Triethylamine → Ethyl 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-8-oxo-8,9-dihydro-7H-purine-6-carboxylate

Participants

Reaction Conditions

Reaction Steps

225 mg (0.55 mmol) of the compound from example 63A were initially charged in dimethylformamide (2.5 ml), then 448 mg (2.76 mmol) of N,N-carbonyldiimidazole and 0.96 ml (6.90 mmol) of triethylamine were added and the mixture was stirred at 100° C. overnight. The reaction mixture was subsequently diluted with water and ethyl acetate, and filtered. The solids were washed with water and, after drying under high vacuum, gave 112 mg (46% of theory) of the title compound.

Provenance & Evidence