HCID 86720055, compound → 2-[5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one

Participants

Reaction Steps

Under an argon atmosphere, 161 mg (0.275 mmol) of the compound from example 131 were dissolved in 15 ml of dimethylformamide, admixed with 100 mg of 10% palladium on charcoal and hydrogenated under standard hydrogen pressure overnight. The reaction mixture was filtered through Celite and concentrated, and the residue was purified by means of preparative HPLC (eluent: water/acetonitrile/water with 1% trifluoroacetic acid, gradient 65:30:5→0:95:5). 41 mg of the title compound were obtained (33% of theory).

Provenance & Evidence