Sodium Hydroxide → HCID 117628654, compound

Participants

Reaction Conditions

Reaction Steps

To ethyl 3-(5-(3-methyl-1-oxo-1-(2,2,2-trifluoroethylamino)butan-2-ylamino)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 3-1a (0.775 g, 1.724 mmol) in methanol (18 mL) was added sodium hydroxide (5.17 ml, 5.17 mmol). The mixture was heated at 50° C. for 18 hrs. The reaction was concentrated in vacuo and aqueous washed with diethyl ether. The aqueous extract was concentrated and 1N HCl added until a precipitate forms (˜pH6). The solid was filtered to give the desired product. 0.467 g. LRMS (ESI) m/z 436.2 [(M+H)+; calcd for C20H20F3N5O3: 436.2.

Provenance & Evidence