Hydrochloric Acid → HCID 86281552, compound

Participants

Reaction Steps

To a solution of Example 17 (224 mg, 0.46 mmol) in MeOH (2 mL) was added 6 M HCl (0.30 mL). The mixture was aged for 3 h and then neutralized with solid NaOH (74 mg, 1.84 mmol) dissolved in a minimum amount of water. The mixture was then concentrated in vacuo. The material was dissolved in DCM and stirred overnight. Filtration removed the inorganic solids and the filtrate was concentrated in vacuo. Chromatography on SiO2 EtOAc/Hex afforded the desired compound as a colorless foam (151 mg, 81%). MS (ESI) mass calcd. C18H13ClF3N5O, 407.08. m/z found 408.1 [M+H]+. 1H NMR (500 MHz, CDCl3): 9.10-8.95 (m, 1H), 7.83-7.77 (m, 1H), 7.76-7.69 (m, 1H), 7.58-7.45 (m, 2H), 7.05-6.89 (m, 1H), 5.18-4.98 (m, 1H), 4.60-4.41 (m, 1H), 4.25-4.04 (m, 1H), 3.64-3.51 (m, 1H), 3.43-3.09 (m, 2H).

Provenance & Evidence