Potassium Hydroxide → HCID 67057969, compound

HRID 510325Notes

Reaction equation

HRID 510325 reaction equation
[OH-].[K+:2].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)[C:11]2[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=2[C:13]([OH:15])=[O:14])=[CH:6][CH:5]=1>C(O)C>[OH:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:20]2[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=2)[C:11]2[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=2[C:13]([O-:15])=[O:14])=[CH:6][CH:5]=1.[K+:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 66494Phenolphthalin

Product 1

HCID 67057969HCID 67057969, compoundYield 100.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Aqueous potassium hydroxide (1 mL of 0.1 N, 0.1 mmol) was added to a solution of 2-(bis-(4-hydroxyphenyl)-methyl)-benzoic acid [32 mg, 0.1 mmol, Adamczyk, M. and Grote, J. Organic Preparations and Procedures International, 2001, 33(1), 95] in 5 mL of ethanol and the mixture was stirred for additional 2 h at room temperature. The mixture was evaporated to dryness under reduced pressure to give 36 mg (100% yield) of the desired compound as a white solid, mp>300° C. 1H NMR (D2O, 300 MHz): δ 6.41 [s, 1H, —CH], 6.66 [d, 4H, J=8.8 Hz, Ar—H], 6.80 [d, 4H, J=8.8 Hz, Ar—H], 7.03 [d, 1H, J=7.7 Hz, Ar—H], 7.35 [t, 1H, J=7.7 Hz, Ar—H], 7.44 [t, 1H, J=7.7 Hz, Ar—H], 7.74 [dd, 1H, J1=7.7 Hz, J2=2.2 Hz, Ar—H].

Workup

  1. customThe mixture was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-0fec452a1e4644cdbf752e2722fe0594
Source dataset
uspto-grants-2015_08
Patent number
US09096607B2

Reaction notes

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