6-Chloro-2-methyl-3-nitropyridine → 6-(3,3-Difluoropiperidin-1-yl)-2-methyl-3-nitropyridine

HRID 510484노트

반응식

HRID 510484 반응식
Cl[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=1.[F:12][C:13]1([F:19])[CH2:18][CH2:17][CH2:16][NH:15][CH2:14]1>>[F:12][C:13]1([F:19])[CH2:18][CH2:17][CH2:16][N:15]([C:2]2[N:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=2)[CH2:14]1

참가 물질

3

반응물 2

HCID 2531236-Chloro-2-methyl-3-nitropyridineHCID 27583503,3-Difluoropiperidine

생성물 1

HCID 895589966-(3,3-Difluoropiperidin-1-yl)-2-methyl-3-nitropyridine

실험 절차

Prepared from 6-chloro-2-methyl-3-nitropyridine and 3,3-difluoropiperidine following the method used to prepare Intermediate 51. LCMS (ES+) 258.05 (M+H)+, RT 3.069 minutes (method 1).

후처리

  1. customLCMS (ES+) 258.05 (M+H)+, RT 3.069 minutes (method 1)

출처 및 근거

ORD 기록
ord-52621314b25d48c0a6f4b0e5f8cf76df
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096614B2

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