Boron tribromide → HCID 57471167, Verbindung

HRID 510497Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 510497
[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[Cl:27])[CH2:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16]C)[CH:14]=2)[CH2:9][CH2:8][CH:7]1[NH:18][C:19](=[O:23])[O:20][CH2:21][CH3:22].B(Br)(Br)Br>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[Cl:27])[CH2:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([OH:16])[CH:14]=2)[CH2:9][CH2:8][CH:7]1[NH:18][C:19](=[O:23])[O:20][CH2:21][CH3:22]

Komponenten

4

Edukt 2

HCID 25134Boron tribromideHCID 57471166HCID 57471166, Verbindung

Produkt 1

HCID 57471167HCID 57471167, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Ethyl 1-(3,4-dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (2.1 g, 5.14 mmol) was dissolved in CH2Cl2 (50 ml) and BBr3 (3.87 g, 15.4 mmol) was added at −10° C. The reaction mixture was slowly warmed to RT and stirred for 2 h. The reaction mixture was added to ice water and extracted with CH2Cl2. The organic layer was washed with NaHCO3 solution and NaCl solution, then dried on MgSO4 and the solvent was removed. The product was obtained as a brown oil (2.05 g, 5.14 mmol, 100%).

Aufarbeitung

  1. extractionextracted with CH2Cl2
  2. washThe organic layer was washed with NaHCO3 solution and NaCl solution
  3. customdried on MgSO4
  4. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-6db3c9feab9c4604b895567f6f2f9ac5
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096619B2

Notizen zur Reaktion

Wird geladen…