Dichloromethane → HCID 57467237, compound

HRID 510521Notes

Reaction equation

HRID 510521 reaction equation
[CH2:1]([S:4]([N:7]1[CH2:10][CH:9]([OH:11])[CH2:8]1)(=[O:6])=[O:5])[CH2:2][CH3:3].[CH3:12][S:13](Cl)(=[O:15])=[O:14].ClCCl>N1C=CC=CC=1>[CH2:1]([S:4]([N:7]1[CH2:8][CH:9]([O:11][S:13]([CH3:12])(=[O:15])=[O:14])[CH2:10]1)(=[O:6])=[O:5])[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 57467236HCID 57467236, compound

Product 1

HCID 57467237HCID 57467237, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 1-(propane-1-sulfonyl)-azetidin-3-ol (236 mg, 1.317 mmol) in pyridine was added drop wise methane sulfonyl chloride (205 μl, 2.63 mmol) at 0° C. The mixture was allowed to warm up to room temperature and was stirred for 3 h. Dichloromethane was added. The mixture was subsequently washed with water, saturated NaHCO3 and brine, dried (MgSO4), and filtrated. The solvent was evaporated to obtain 293 mg of crude product which was used without further purification.

Workup

  1. washThe mixture was subsequently washed with water, saturated NaHCO3 and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltrated
  4. customThe solvent was evaporated

Sources & evidence

ORD record
ord-1852fc6a9eb7444ba46387d9988ba605
Source dataset
uspto-grants-2015_08
Patent number
US09096619B2

Reaction notes

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