1-Propanesulfonyl chloride → Propane-1-Sulfonic Acid Cyclopropyl Amide

HRID 510553ノート

反応式

HRID 510553 の反応式
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[CH2:5]([S:8](Cl)(=[O:10])=[O:9])[CH2:6][CH3:7]>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH:1]1([NH:4][S:8]([CH2:5][CH2:6][CH3:7])(=[O:10])=[O:9])[CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 662791-Propanesulfonyl chlorideHCID 69828Cyclopropylamine

生成物 1

HCID 59547736Propane-1-Sulfonic Acid Cyclopropyl Amide収率 98%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒3 回

実験手順

To a solution of cyclopropylamine (1.2 ml, 17.5 mmol) in 100 ml CH2Cl2 and DMAP (2.4 g, 17.5 mmol) was added dropwise a solution of propane-1-sulfonyl chloride (2.3 ml, 19.2 mmol) in 50 ml CH2Cl2. The resulting mixture was stirred at room temperature over night and diluted with 50 ml of CH2Cl2. The mixture was extracted subsequently with water, 1 M HCl, and brine, tried over Na2SO4, filtered and the solvent evaporated to obtain 2.8 g of product (oil) which was used in the next step without further purification.

後処理

  1. extractionThe mixture was extracted subsequently with water, 1 M HCl, and brine
  2. filtrationfiltered
  3. customthe solvent evaporated

出典と根拠

ORDレコード
ord-1bbe9d9c09c14b35be07ba5da9a6389a
出典データセット
uspto-grants-2015_08
特許番号
US09096619B2

反応ノート

読み込み中…