Potassium Hydroxide → Propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide

HRID 510555ノート

反応式

HRID 510555 の反応式
[CH:1]1([N:4]([S:11]([CH2:14][CH2:15][CH3:16])(=[O:13])=[O:12])[CH2:5][CH2:6][O:7]C(=O)C)[CH2:3][CH2:2]1.[OH-].[K+]>CO>[CH:1]1([N:4]([CH2:5][CH2:6][OH:7])[S:11]([CH2:14][CH2:15][CH3:16])(=[O:13])=[O:12])[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 59547802Acetic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester

生成物 1

HCID 43577530Propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide収率 32.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of acetic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester (1.7 g, 6.8 mmol) and KOH (0.57 g, 10.2 mmol) in 30 ml Methanol was stirred over night at room temperature. The solvent was evaporated the residue dissolved in ethyl acetate and subsequently extracted with water and 1 M KOH, dried over Na2SO4 and the solvent evaporated to obtain 0.46 g of product which was used purified by chromatography (253.5 mg of colorless oil)

後処理

  1. customThe solvent was evaporated the residue
  2. dissolutiondissolved in ethyl acetate
  3. extractionsubsequently extracted with water and 1 M KOH
  4. dry with materialdried over Na2SO4
  5. customthe solvent evaporated

出典と根拠

ORDレコード
ord-c24b2a99f0824004927baf70fcc06bf4
出典データセット
uspto-grants-2015_08
特許番号
US09096619B2

反応ノート

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