反应详情

To a solution of methyl cyclopentanecarboxylate (300 mg, 2.3 mmol) in THF (20 ml) at −78° C. was added LHMDS (4.6 mL, 4.6 mmol) and stirred for 30 min, and followed by 1-bromo-5-methylhexane (626 mg, 3.5 mmol). The mixture was stirred from −78° C. to rt over 16 hr, before 30 ml of H2O was added and then was extracted with CH2Cl2 (2×30 mL). The combined extracts were washed with water, dried over MgSO4, filtered and concentrated, then purified using flash chromatography to give an oil (110 mg, 21%). MS [M+H]+333.

1. additionwas added
2. extractionwas extracted with CH2Cl2 (2×30 mL)
3. washThe combined extracts were washed with water
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated
7. custompurified