Hydrochloric Acid → 2-(4-Chlorophenyl)cyclopropan-1-amine hydrochloride

HRID 510667ノート

反応式

HRID 510667 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH:9]2[NH:11]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.Cl.O1CCOCC1>ClCCl>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:10][CH:9]2[NH2:11])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67080543Tert-butyl 2-(4-chlorophenyl)cyclopropylcarbamate

生成物 1

HCID 462211102-(4-Chlorophenyl)cyclopropan-1-amine hydrochloride収率 198.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

tert-Butyl 2-(4-chlorophenyl)cyclopropylcarbamate (51.9 mg, 0.1938 mmol) was dissolved in Dichloromethane (1 ml) and 4M HCl solution in dioxane (0.4846 ml, 1.938 mmol) was added. The mixture was stirred for 3 hours at ambient temperature, during which time a white solid precipitated out of solution. The crude mixture was concentrated and chased with EtOAc (2×10 ml). The residual fine solid was dried under high vacuum to provide 39.2 mg of the title compound as a solid (99%).

後処理

  1. customprecipitated out of solution
  2. concentrationThe crude mixture was concentrated
  3. customThe residual fine solid was dried under high vacuum

出典と根拠

ORDレコード
ord-620126016fe54cf19f21bb3a5dc9d4ed
出典データセット
uspto-grants-2015_08
特許番号
US09096567B2

反応ノート

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