4-Chloro-2-fluorobenzaldehyde → 4-Chloro-2-methoxybenzaldehyde

HRID 510693노트

반응식

HRID 510693 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4](F)[CH:3]=1.[CH3:11][O-:12].[Na+]>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([O:12][CH3:11])[CH:3]=1

참가 물질

3

반응물 2

HCID 27249084-Chloro-2-fluorobenzaldehydeHCID 10942334Sodium Methoxide

생성물 1

HCID 138651154-Chloro-2-methoxybenzaldehyde수율 77.8%

반응 조건

온도
50 °C

실험 절차

4-Chloro-2-Fluorobenzaldehyde (300 mg, 1.89 mmol) was diluted with NaOMe (3784 μL, 1.89 mmol) (solution in methanol), heated to 50° C. and stirred for 3 hours. The reaction was concentrated in half and loaded directly onto a biotage 25 cartridge eluting with 5% ethyl acetate/hexanes to yield 4-chloro-2-methoxybenzaldehyde (250 mg, 1.47 mmol, 77.5% yield).

후처리

  1. concentrationThe reaction was concentrated in half
  2. washeluting with 5% ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-bdfaa320f59e45ef8d347a3303fd0a51
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096567B2

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