Hydroxylamine → 3-Phenylcyclohexanone oxime

HRID 510754ノート

反応式

HRID 510754 の反応式
[C:1]1([CH:7]2[CH2:12][CH2:11][CH2:10][C:9](=O)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][OH:15].O>C(O)C.CCOC(C)=O>[C:1]1([CH:7]2[CH2:12][CH2:11][CH2:10][C:9](=[N:14][OH:15])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 3

HCID 787HydroxylamineHCID 962WaterHCID 2736613-Phenylcyclohexanone

生成物 1

HCID 866532373-Phenylcyclohexanone oxime収率 92.07%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 3-phenylcyclohexanone (0.060 g, 0.3444 mmol) in 95% ethanol (2 ml) was added 50% hydroxylamine in water (0.2110 ml, 3.444 mmol), and the reaction was stirred at ambient temperature overnight. The reaction was diluted with EtOAc and washed with water and saturated sodium chloride. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated to yield 60 mg of the title compound (92.07% yield).

後処理

  1. washwashed with water and saturated sodium chloride
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-e86355f496e74c9d9782e4b8a543b6bc
出典データセット
uspto-grants-2015_08
特許番号
US09096567B2

反応ノート

読み込み中…