HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → (2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine | HCID 57043207 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine | HCID 57048351 | 41.7% |
Reaction Steps
The procedure described in Preparation 5-(4) was repeated, but using 2 g of (2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine, 35% formalin and 848 mg of sodium cyanoborohydride in the presence of 44 ml of acetonitrile, to afford 883 mg of the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242914 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-1fc826cd6595419badb8308649438ba2 |
| Source note | uspto-grants-1993_09 |