HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Chloro-3'-fluoro-5-methyl-6-nitrobiphenyl-2-yl)ethanone → 1-(6-Amino-4-chloro-3'-fluoro-5-methylbiphenyl-2-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Chloro-3'-fluoro-5-methyl-6-nitrobiphenyl-2-yl)ethanone | HCID 86656186 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(6-Amino-4-chloro-3'-fluoro-5-methylbiphenyl-2-yl)ethanone | HCID 58368430 | 102.9% |
Reaction Steps
A mixture of 1-(4-chloro-3′-fluoro-5-methyl-6-nitrobiphenyl-2-yl)ethanone (4.4 g, 14 mmol) in methanol (80 mL) was hydrogenated in the presence of 5% Pt/C (443 mg) under balloon pressure of hydrogen overnight. The catalyst was filtered and the filtrate was concentrated under reduced pressure to give the desired product (4.0 g, 100%). LCMS calculated for C15H14ClFNO (M+H)+: m/z=278.1. found: 278.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09096600B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-3a71dd4d93a9479d8375f7d31f067069 |
| Source note | uspto-grants-2015_08 |