Methyl iodide → HCID 10203135, compound

HRID 51085Notes

Reaction equation

HRID 51085 reaction equation
[Cl:1][C:2]1[CH:27]=[C:26]([C:28]([CH3:31])([CH3:30])[CH3:29])[CH:25]=[CH:24][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][CH:15]([C:19]([O:21]CC)=[O:20])[O:16]2)=[CH:11][CH:10]=1.I[CH3:33]>>[Cl:1][C:2]1[CH:27]=[C:26]([C:28]([CH3:31])([CH3:29])[CH3:30])[CH:25]=[CH:24][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][C:15]([CH3:33])([C:19]([OH:21])=[O:20])[O:16]2)=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 22737352HCID 22737352, compound

Product 1

HCID 10203135HCID 10203135, compound

Procedure

The title compound was prepared from ethyl 7-(3-(2-chloro-4-tert-butylphenoxy)propoxy)-chromane-2-carboxylate following the procedures described in Example 1, Step C employing iodomethane instead of iodoethane, followed by hydrolysis as described in Example 1, Step G.

Workup

  1. customfollowed by hydrolysis

Sources & evidence

ORD record
ord-8708f3fbe64f4ca3b1d2a8f8d8a7b3df
Source dataset
uspto-grants-2004_03
Patent number
US06713508B2

Reaction notes

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