Ammonium Acetate → 6-(1-Aminoethyl)-4-chloro-3',5'-difluoro-3-methylbiphenyl-2-carboxamide

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Reaction Conditions

Reaction Steps

A mixture of 6-acetyl-4-chloro-3′,5′-difluoro-3-methylbiphenyl-2-carboxamide (61 mg, 0.19 mmol), ammonium acetate (150 mg, 1.9 mmol) and sodium cyanoborohydride (24 mg, 0.38 mmol) in methanol (0.7 mL) and acetonitrile (0.7 mL) was heated at 65° C. overnight in a sealed tube. The mixture was then cooled to room temperature, quenched with saturated sodium bicarbonate and extracted with ethyl acetate. The combined extracts were dried over magnesium sulfate and evaporated to dryness. The crude product was used directly in next step (61 mg, 99%). LCMS calculated for C16H13ClF2NO (M−NH2)+: m/z=308.1. found: 308.0.

Provenance & Evidence