Ammonia → HCID 88536176, compound

HRID 510876Notes

Reaction equation

[C:1]([C:4]1[C:5]([O:23][CH3:24])=[C:6]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([C:19](OC)=[O:20])[CH:13]=2)[C:7]([CH3:11])=[C:8]([Cl:10])[CH:9]=1)(=[O:3])[CH3:2].[NH3:25].CO>>[C:1]([C:4]1[C:5]([O:23][CH3:24])=[C:6]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([C:19]([NH2:25])=[O:20])[CH:13]=2)[C:7]([CH3:11])=[C:8]([Cl:10])[CH:9]=1)(=[O:3])[CH3:2]

Participants

Reactant 3

HCID 222Ammonia

HCID 887Methanol

HCID 88536311HCID 88536311, compound

Product 1

HCID 88536176HCID 88536176, compound

Conditions

Temperature: 90 °C

Procedure

A mixture of methyl 3′-acetyl-5′-chloro-4-fluoro-2′-methoxy-6′-methylbiphenyl-3-carboxylate (50 mg, 0.1 mmol) and 7.0 M ammonia in methanol (2.0 mL, 14 mmol) was heated at 90° C. in a sealed tube overnight. After evaporating the mixture to dryness, the residue was used directly in next step. LCMS calculated for C17H16ClFNO3 (M+H)+: m/z=336.1. found: 336.0.

Workup

customAfter evaporating the mixture to dryness

Sources & evidence

ORD record: ord-98a0cfd46ca945a3bff5bc72468ad3e7
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09096600B2

Reaction notes

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